Problem: The Man with the Golden Arm is a 1955 American drama film with elements of film noir, based on the novel of the same name by Nelson Algren, which tells the story of a drug addict who gets clean while in prison, but struggles to stay that way in the outside world. Although the addictive drug is never identified in the film, according to the American Film Institute "most contemporary and modern sources assume that it is heroin", in contrast to Algren's book which named the drug as morphine. The film stars Frank Sinatra, Eleanor Parker, Kim Novak, Arnold Stang and Darren McGavin. It was adapted for the screen by Walter Newman, Lewis Meltzer and Ben Hecht (uncredited), and directed by Otto Preminger.

Screen rights to Algren's novel were first acquired in 1949 on behalf of John Garfield, who planned to star in the film version. However, production was delayed because the Production Code Authority (PCA) refused to approve the script, with Joseph Breen stating that the basic story was "unacceptable" because of the Code's prohibition on showing illegal drug trafficking and drug addiction. The ability to obtain PCA approval was critical because at that time, many movie theaters would not show films that had not received approval. The PCA further predicted that the subject would also be unacceptable to the National Legion of Decency (a Catholic film censor board), Federal authorities, and state and local censor boards in the United States and abroad. Garfield died in 1952 and director Otto Preminger acquired the rights from his estate.  Preminger had previously released The Moon Is Blue (1953), which succeeded at the box office despite being denied the Production Code seal of approval due to its sexual subject matter. He told Peter Bogdanovich why he was attracted to Algren's novel: "I think there's a great tragedy in any human being who gets hooked on something, whether it's heroin or love or a woman or whatever." Although United Artists (UA) had a distribution contract with Preminger, a clause in the contract allowed them to withdraw if a film failed to get Code approval. Preminger stated that in that event, he would set up his own company to handle distribution of The Man With The Golden Arm. Preminger continued to have problems with the PCA during the making of the film.  Although the novel's author, Nelson Algren, was initially brought to Hollywood to work on the screenplay, he and Preminger did not get along, and he was quickly replaced by Walter Newman. Preminger and Newman went on to make significant changes to Algren's original story, and the film was eventually released as "A Film By Otto Preminger". In 1956, Algren sued Preminger and others seeking an injunction to keep Preminger from claiming authorship of the film, but had to drop the suit because he could not afford the legal fees.  Frank Sinatra jumped at a chance to star in the film before reading the entire script. The script was given to Marlon Brando around the same time as Sinatra, who still harbored some anger at Brando for beating out Sinatra for the lead role in On the Waterfront. To prepare for his role, Sinatra spent time at drug rehabilitation clinics observing addicts going cold turkey. He also learned to play drums from drummer Shelly Manne. The picture was shot in six weeks at RKO Studios in Hollywood from September 26 through November 4, 1955.  Saul Bass designed the crooked arm symbol used in the film's advertising campaign, which Preminger liked so much that he threatened to pull the picture if an exhibitor changed the advertisements. Bass also created the animated title sequence for the film, the first of many such sequences that he created for films by Preminger, Alfred Hitchcock, and others.

Was there any difficulties during the production of the film?

Answer with quotes: However, production was delayed because the Production Code Authority (PCA) refused to approve the script, with Joseph Breen stating that the basic story was "unacceptable"


Problem: John Craig Venter (born October 14, 1946) is an American biotechnologist, biochemist, geneticist, and businessman. He is known for being involved with sequencing the second human genome and assembled the first team to transfect a cell with a synthetic chromosome. Venter founded Celera Genomics, The Institute for Genomic Research (TIGR) and the J. Craig Venter Institute (JCVI). He was the co-founder of Human Longevity Inc., served as its CEO until 2017, and is executive chairman of the board of directors.

Venter was passionate about the power of genomics to radically transform healthcare. Venter believed that shotgun sequencing was the fastest and most effective way to get useful human genome data. The method was rejected by the Human Genome Project however, since some geneticists felt it would not be accurate enough for a genome as complicated as that of humans, that it would be logistically more difficult, and that it would cost significantly more.  Venter viewed the slow pace of progress in the Human Genome project as an opportunity to continue his interest in patenting genes, so he sought funding from the private sector to birth Celera Genomics. The company planned to profit from their work by creating genomic data to which users could subscribe for a fee. The goal consequently put pressure on the public genome program and spurred several groups to redouble their efforts to produce the full sequence. Venter's effort to publish a draft genome of his own DNA won him renown as the second person to sequence the human genome after the public effort, thus making it impossible to patent any of it.  In 2000, Venter and Francis Collins of the National Institutes of Health and U.S. Public Genome Project jointly made the announcement of the mapping of the human genome, a full three years ahead of the expected end of the Public Genome Program. The announcement was made along with U.S. President Bill Clinton, and UK Prime Minister Tony Blair. Venter and Collins thus shared an award for "Biography of the Year" from A&E Network. On the 15 February 2001, the Human Genome Project consortium published the first Human Genome in the journal Nature, and was followed, one day later, by a Celera publication in Science. Despite some claims that shotgun sequencing was in some ways less accurate than the clone-by-clone method chosen by the Human Genome Project, the technique became widely accepted by the scientific community.  Venter was fired by Celera in early 2002. According to his biography, Venter was fired due to a conflict with the main investor, Tony White, specifically barring him from attending the White House ceremony celebrating the achievement of sequencing the human genome.

What did he do after that?

Answer with quotes:
The announcement was made along with U.S. President Bill Clinton, and UK Prime Minister Tony Blair. Venter