Answer the question at the end by quoting:

Afonso de Albuquerque was born in 1453 in Alhandra, near Lisbon. He was the second son of Goncalo de Albuquerque, Lord of Vila Verde dos Francos, and Dona Leonor de Menezes. His father held an important position at court and was connected by remote illegitimate descent with the Portuguese monarchy. He was educated in mathematics and Latin at the court of Afonso V of Portugal, where he befriended Prince John, the future King John II of Portugal.
The fleet left Lisbon on 6 April 1506. Afonso piloted his ship himself, having lost his appointed pilot on departure. In Mozambique Channel, they rescued Captain Joao da Nova, who had encountered difficulties on his return from India; da Nova and his ship, the Frol de la mar, joined da Cunha's fleet. From Malindi, da Cunha sent envoys to Ethiopia, which at the time was thought to be closer than it actually is. Those included the priest Joao Gomes, Joao Sanches and Tunisian Sid Mohammed who, having failed to cross the region, headed for Socotra; from there, Afonso managed to land them in Filuk. After successful attacks on Arab cities on the east Africa coast, they conquered Socotra and built a fortress at Suq, hoping to establish a base to stop the Red Sea commerce to the Indian Ocean. However, Socotra was abandoned four years later, as it was not advantageous as a base.  At Socotra, they parted ways: Tristao da Cunha sailed for India, where he would relieve the Portuguese besieged at Cannanore, while Afonso took seven ships and 500 men to Ormuz in the Persian Gulf, one of the chief eastern centers of commerce. On his way, he conquered the cities of Curiati (Kuryat), Muscat in July 1507, and Khor Fakkan, accepting the submission of the cities of Kalhat and Sohar. He arrived at Ormuz on 25 September and soon captured the city, which agreed to become a tributary state of the Portuguese king.  Hormuz was then a tributary state of Shah Ismail of Persia. In a famous episode, shortly after it's conquest Albuquerque was confronted by Persian envoys, who demanded the payment of the due tribute from him instead. He ordered them be given a stock of cannonballs, arrows and weapons, retorting that "such was the currency struck in Portugal to pay the tribute demanded from the dominions of King Manuel"  According to Bras de Albuquerque, it was Shah Ismael who coined the term "Lion of the seas", addressing Albuquerque as such. Afonso began building the Fort of Our Lady of Victory (later renamed Fort of Our Lady of the Conception), engaging his men of all ranks in the work.  However, some of his officers revolted against the heavy work and climate and, claiming that Afonso was exceeding his orders, departed for India. With the fleet reduced to two ships and left without supplies, he was unable to maintain this position for long. Forced to abandon Ormuz in January 1508, he raided coastal villages to resupply the settlement of Socotra, returned to Ormuz, and then headed to India.

Where did they take off to?

Afonso took seven ships and 500 men to Ormuz in the Persian Gulf,

IN: Gloria Estefan (nee Fajardo; born September 1, 1957) is a Cuban-American singer, songwriter, actress, and businesswoman. She started off her career as the lead singer in the group called "Miami Latin Boys" which was eventually known as Miami Sound Machine. Estefan's breakthrough success with "Conga" in 1985 made her known worldwide. The song became Estefan's signature song and led to the Miami Sound Machine winning the grand prix in the 15th annual Tokyo Music Festival in 1986.

Starting in 1977, Miami Sound Machine began recording and releasing various albums and 45s on the Audiofon Records label in Miami. The first album from 1977 was entitled Live Again/Renacer and was released with two different covers. After several more releases on the Audiofon label as well as the RCA Victor label and Miami Sound Machine's own label MSM Records, the band was signed to Discos CBS International and released several albums, 45s, and 12"s beginning with the 1978 self-titled album Miami Sound Machine. Growing in popularity in both the U.S. and around the world, the group would continue recording and issuing various works for Discos CBS International through 1985.  In 1984, Miami Sound Machine released their first Epic/Columbia album, Eyes of Innocence, which contained the dance hit "Dr. Beat" as well as the ballad "I Need Your Love". Their more successful follow-up album Primitive Love was released in 1985 launching three Top 10 hits on the Billboard Hot 100: "Conga" (U.S. No. 10), "Words Get in the Way" (U.S. No. 5), and "Bad Boy" (U.S. No. 8), as well as "Falling in Love (Uh-Oh)" (U.S. No. 25) which became follow up hits in the U.S. and around the world. "Words Get in the Way" reached No. 1 on the US Hot Adult Contemporary Tracks chart, establishing that the group could perform pop ballads as successfully as dance tunes. The song "Hot Summer Nights" was also released that year and was part of the film Top Gun.  Their next album, 1987's Let It Loose, went multi-platinum, with three million copies sold in the US alone. It featured the following hits: "Anything for You" (No. 1 Hot 100), "1-2-3" (No. 3 Hot 100), "Betcha Say That" (No. 36 Hot 100), "Rhythm Is Gonna Get You" (No. 5 Hot 100), and "Can't Stay Away from You" (No. 6 Hot 100). "Can't Stay Away From You", "Anything for You", and "1-2-3" were all No. 1 Adult Contemporary hits as well. In that same year, Estefan took top billing and the band's name changed to Gloria Estefan and Miami Sound Machine.  In 1989, the group's name was dropped, and Estefan has been credited as a solo artist ever since. In 1988, after the worldwide chart success of single "Anything for You", her Let it Loose album was repackaged as Anything for You.

What was their biggest hit?

OUT:
Words Get in the Way" reached No. 1 on the US Hot Adult Contemporary Tracks