Question: Henrietta Lacks (born Loretta Pleasant; August 1, 1920 - October 4, 1951) was an African-American woman whose cancer cells are the source of the HeLa cell line, the first immortalized cell line and one of the most important cell lines in medical research. An immortalized cell line will reproduce indefinitely under specific conditions, and the HeLa cell line continues to be a source of invaluable medical data to the present day. Lacks was the unwitting source of these cells from a tumor biopsied during treatment for cervical cancer at Johns Hopkins Hospital in Baltimore, Maryland, U.S., in 1951. These cells were then cultured by George Otto Gey who created the cell line known as HeLa, which is still used for medical research.

George Otto Gey, the first researcher to study Lacks's cancerous cells, observed that her cells were unique in that they reproduced at a very high rate and could be kept alive long enough to allow more in-depth examination. Until then, cells cultured for laboratory studies survived for only a few days at most, which wasn't long enough to perform a variety of different tests on the same sample. Lacks's cells were the first to be observed that could be divided multiple times without dying, which is why they became known as "immortal." After Lacks' death, Gey had Mary Kubicek, his lab assistant, took further HeLa samples while Henrietta's body was at Johns Hopkins' autopsy facility. The roller-tube technique was the method used to culture the cells obtained from the samples that Kubicek collected. Gey was able to start a cell line from Lacks's sample by isolating one specific cell and repeatedly dividing it, meaning that the same cell could then be used for conducting many experiments. They became known as HeLa cells, because Gey's standard method for labeling samples was to use the first two letters of the patient's first and last names.  The ability to rapidly reproduce HeLa cells in a laboratory setting has led to many important breakthroughs in biomedical research. For example, by 1954, Jonas Salk was using HeLa cells in his research to develop the polio vaccine. To test his new vaccine, the cells were mass-produced in the first-ever cell production factory. Additionally, Chester M. Southam, a leading virologist, injected HeLa cells into cancer patients, prison inmates, and healthy individuals in order to observe whether cancer could be transmitted as well as to examine if one could become immune to cancer by developing an acquired immune response.  HeLa cells were in high demand and put into mass production. They were mailed to scientists around the globe for "research into cancer, AIDS, the effects of radiation and toxic substances, gene mapping, and countless other scientific pursuits". HeLa cells were the first human cells successfully cloned in 1955, and have since been used to test human sensitivity to tape, glue, cosmetics, and many other products. Since the 1950s, scientists have grown 20 tons of her cells, and there are almost 11,000 patents involving HeLa cells.  In the early 1970s, a large portion of other cell cultures became contaminated by HeLa cells. As a result, members of Henrietta Lacks's family received solicitations for blood samples from researchers hoping to learn about the family's genetics in order to differentiate between HeLa cells and other cell lines.  Alarmed and confused, several family members began questioning why they were receiving so many telephone calls requesting blood samples. In 1975, the family also learned through a chance dinner-party conversation that material originating in Henrietta Lacks was continuing to be used for medical research. The family had never discussed Henrietta's illness and death among themselves in the intervening years but with the increased curiosity about their mother and her genetics, they now began to ask questions.

Using a quote from the above article, answer the following question: How was Lacks involved in medical research?
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Answer: Lacks's cancerous cells, observed that her cells were unique in that they reproduced at a very high rate and could be kept alive long enough to allow more in-depth examination.


Question: Richard "Red" Skelton (July 18, 1913 - September 17, 1997) was an American comedy entertainer. He was best known for his national radio and television acts between 1937 and 1971, and as host of the television program The Red Skelton Show. He has stars on the Hollywood Walk of Fame for his work in radio and television, and also appeared in burlesque, vaudeville, films, nightclubs, and casinos, all while he pursued an entirely separate career as an artist. Skelton began developing his comedic and pantomime skills from the age of 10, when he became part of a traveling medicine show.

Skelton and Edna worked for a year in Camden, New Jersey, and were able to get an engagement at Montreal's Lido Club in 1934 through a friend who managed the chorus lines at New York's Roxy Theatre. Despite an initial rocky start, the act was a success, and brought them more theater dates throughout Canada.  Skelton's performances in Canada led to new opportunities and the inspiration for a new, innovative routine that brought him recognition in the years to come. While performing in Montreal, the Skeltons met Harry Anger, a vaudeville producer for New York City's Loew's State Theatre. Anger promised the pair a booking as a headlining act at Loew's, but they would need to come up with new material for the engagement. While the Skeltons were having breakfast in a Montreal diner, Edna had an idea for a new routine as she and Skelton observed the other patrons eating doughnuts and drinking coffee. They devised the "Doughnut Dunkers" routine, with Skelton's visual impressions of how different people ate doughnuts. The skit won them the Loew's State engagement and a handsome fee.  The couple viewed the Loew's State engagement in 1937 as Skelton's big chance. They hired New York comedy writers to prepare material for the engagement, believing they needed more sophisticated jokes and skits than the routines Skelton normally performed. However, his New York audience did not laugh or applaud until Skelton abandoned the newly written material and began performing the "Doughnut Dunkers" and his older routines. The doughnut-dunking routine also helped Skelton rise to celebrity status. In 1937, while he was entertaining at the Capitol Theater in Washington, D.C., President Franklin D. Roosevelt invited Skelton to perform at a White House luncheon. During one of the official toasts, Skelton grabbed Roosevelt's glass, saying, "Careful what you drink, Mr. President. I got rolled in a place like this once." His humor appealed to FDR and Skelton became the master of ceremonies for Roosevelt's official birthday celebration for many years afterward.

Using a quote from the above article, answer the following question: Did this lead to bigger adventures?
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Answer:
The couple viewed the Loew's State engagement in 1937 as Skelton's big chance.