Melanie Jayne Chisholm was born in Whiston, Lancashire, as the only child in the family. She later moved to Widnes, Cheshire, at a young age. Her parents married on 12 January 1971 and separated in 1978, when young Chisholm was four-and-a-half years old. Her father, Alan Chisholm, worked as a fitter at the Otis Elevator Company.

Chisholm began recording her second album in late 2001. She traveled to the United States to record some songs. During this time, she recorded "Independence Day" from the film soundtrack Bend It Like Beckham and wrote "Help Me Help You" for Holly Valance, included in her album Footprints. Chisholm, along with American singer Anastacia made an appearance at the 2002 MTV Europe Music Awards to present the award for "Best Song", which was given to P!nk.  Chisholm's second album was originally planned to be released on 16 September 2002, then postponed to 24 February 2003. It was finally postponed to 10 March 2003. Rumors at the time speculated that Chisholm and Virgin had several conflicts, because they wanted her to lose weight. Chisholm also took time out due to struggles with clinical depression. On 24 February 2003 the first single from her new album was released, "Here It Comes Again", which reached number 7 in the UK and peaked in the top 20 in Spain and Ireland. She released her second studio album, Reason, on 10 March 2003 and it peaked at number 5, received gold certification in the UK. The label sent Chisholm to promote the album, including several pocket shows. On 24 April 2003, she embarked in the Reason Tour, traveling only in Europe. The second single, "On the Horizon", was released on 2 June 2003. After the previous single, the music critics were predicting that this single would redeem Chisholm's chart success, but the song peaked at number 14 and did not help sales.  "Let's Love", was released as a single exclusively in Japan and used for a Toyota Motor Corporation commercial. Originally, "Yeh Yeh Yeh" was planned to be released as the third and final single on 22 September 2003, but shortly before this could happen, Chisholm injured her knee during the television show The Games and couldn't fully promote an upbeat song with an injury. "Melt" was then chosen to be launched along with "Yeh Yeh Yeh" as a double A-side, because she could do a small number of performances. The double single was released on 10 November 2003. The song peaked at number 27. In other countries of Europe, "Melt" wasn't released, only "Yeh Yeh Yeh" as a solo release. After the release of "Melt/Yeh Yeh Yeh", Melanie added some extra dates to the Reason Tour, and the Avo Session Basel concert was broadcast on 3sat.

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