Background: Rogen was born in Vancouver, British Columbia. His mother, Sandy (nee Belogus), is a social worker, and his father, Mark Rogen, worked for non-profit organizations and as an assistant director of the Workmen's Circle Jewish fraternal organization. Since Rogen's father is American, he has American citizenship by birth, though the actor has stated "I definitely associate with being Canadian much more than being American" because he grew up in Canada. He has described his parents, who met on kibbutz Beit Alfa in Israel, as "radical Jewish socialists".
Context: Rogen began dating writer/actress Lauren Miller in 2004. The two met while he was working on Da Ali G Show. The couple became engaged on September 29, 2010, and married on October 2, 2011 in Sonoma County, California, where they continue to reside. Miller has had minor on-screen roles in a few of Rogen's films.  Rogen has been outspoken about awareness of Alzheimer's disease. No one in his biological family has it but it runs in his wife's side, and has affected her mother for several years. "I think until you see it firsthand, it's kind of hard to conceive of how brutal it is," Rogen said to CNN. "Until I saw it, you just don't get kind of how heartbreaking it can be." During the interview, he talked about how he tries to be emotionally supportive and around as much as he can for Miller's mother. Both he and Miller spoke to Larry King for A Larry King Special, Unthinkable: The Alzheimer's Epidemic, which aired in April 2011. Rogen testified about the disease and his charity before the United States Senate Appropriations Subcommittee on Labor, Health and Human Services on February 26, 2014. Rogen started the Hilarity for Charity movement, to inspire change and raise awareness of Alzheimer's disease among the Millennial Generation. On February 25, 2016, Rogen and Miller were honored with the unite2gether accolade from unite4:humanity for their work promoting awareness and raising money for Alzheimer's research through Hilarity for Charity.  Rogen appeared in a Bud Light commercial celebrating LGBT Pride Month and the Supreme Court of the United States ruling same-sex couples the right to marry. He is a purported muse for the gay community, calling himself a "Bear Icon" in an appearance on Conan. Rogen is a member of Pi Kappa Alpha fraternity (Lambda Delta chapter) at the University of Vermont. He was initiated in April 2017 after his fourth visit to the campus for his Hilarity for Charity movement. Rogen is also a member of National Organization for the Reform of Marijuana Laws and an open marijuana user.
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Rogen has been outspoken about awareness of Alzheimer's disease.