Answer the question at the end by quoting:

Alice Hamilton (February 27, 1869 - September 22, 1970) was an American physician, research scientist, and author who is best known as a leading expert in the field of occupational health and a pioneer in the field of industrial toxicology. She was also the first woman appointed to the faculty of Harvard University. Her scientific research focused on the study of occupational illnesses and the dangerous effects of industrial metals and chemical compounds. In addition to her scientific work, Hamilton was a social-welfare reformer, humanitarian, peace activist, and a resident-volunteer at Hull House in Chicago.
Hamilton began her long career in public health and workplace safety in 1910, when Illinois governor Charles S. Deneen appointed her as a medical investor to the newly-formed Illinois Commission on Occupational Diseases. Hamilton lead the commission's investigations, which focused on industrial poisons such as lead and other toxins. She also authored the "Illinois Survey," the commission's report that documented its findings of industrial processes that exposed workers to lead poisoning and other illnesses. The commission's efforts resulted in the passage of the first workers' compensation laws in Illinois in 1911, in Indiana in 1915, and occupational disease laws in other states. The new laws required employers to take safety precautions to protect workers.  By 1916 Hamilton had become America's leading authority on lead poisoning. For the next decade she investigated a range of issues for a variety of state and federal health committees. Hamilton focused her explorations on occupational toxic disorders, examining the effects of substances such as aniline dyes, carbon monoxide, mercury, tetraethyl lead, radium, benzene, carbon disulfide and hydrogen sulfide gases. In 1925, at a Public Health Service conference on the use of lead in gasoline, she testified against the use of lead and warned of the danger it posed to people and the environment. Nevertheless, leaded gasoline was allowed. The EPA in 1988 estimated that over the previous 60 years that 68 million children suffered high toxic exposure to lead from leaded fuels. Her work on the manufacture of white lead and lead oxide, as a special investigator for the U.S. Bureau of Labor Statistics, is considered a "landmark study". Relying primarily on "shoe leather epidemiology" (her process of making personal visits to factories, conducting interviews with workers, and compiling details of diagnosed poisoning cases) and the emerging laboratory science of toxicology, Hamilton pioneered occupational epidemiology and industrial hygiene. She also created the specialized field of industrial medicine in the United States. Her findings were scientifically persuasive and influenced sweeping health reforms that changed laws and general practice to improve the health of workers.  During World War I, the US Army tasked her with solving a mysterious ailment striking workers at a munitions plant in New Jersey. She led a team that included George Minot, a Professor at Harvard Medical School. She deduced that the workers were being sickened through contact with the explosive trinitrotoluene (TNT). Her recommendations that workers wear protective clothing that should be removed and washed at the end of each shift solved the problem.  Hamilton's best-known research included her studies on carbon monoxide poisoning among American steelworkers, mercury poisoning of hatters, and "a debilitating hand condition developed by workers using jackhammers." At the request of the U.S. Department of Labor, she also investigated industries involved in developing high explosives, "spastic anemia known as 'dead fingers'" among Bedford, Indiana, limestone cutters, and the "unusually high incidence of pulmonary tuberculosis" among tombstone carvers working in the granite mills of Quincy, Massachusetts, and Barre, Vermont. Hamilton was also a member of the Committee for the Scientific Investigation of the Mortality from Tuberculosis in Dusty Trades, whose efforts "laid the groundwork for further studies and eventual widespread reform in the industry."

what else did it include?

The EPA in 1988 estimated that over the previous 60 years that 68 million children suffered high toxic exposure to lead from leaded fuels.



Answer the question at the end by quoting:

For the theatre adaptation, see Shakespeare in Love (play). Shakespeare in Love is a 1998 American romantic period comedy-drama film directed by John Madden, written by Marc Norman and playwright Tom Stoppard. The film depicts an imaginary love affair involving Viola de Lesseps (Gwyneth Paltrow) and playwright William Shakespeare (Joseph Fiennes) while he was writing Romeo and Juliet. Several characters are based on historical figures, and many of the characters, lines, and plot devices allude to Shakespeare's plays.
The original idea for Shakespeare in Love came to screenwriter Marc Norman in the late 1980s after a rudimentary pitch from his son Zachary. Norman wrote a draft screenplay which he presented to director Edward Zwick, which attracted Julia Roberts, who agreed to play Viola. However, Zwick disliked Norman's screenplay and hired the playwright Tom Stoppard to improve it (Stoppard's first major success had been with the Shakespeare-themed play Rosencrantz & Guildenstern Are Dead).  The film went into production in 1991 at Universal, with Zwick as director, but although sets and costumes were in construction, Shakespeare had not yet been cast, because Roberts insisted that only Daniel Day-Lewis could play the role. Day-Lewis was uninterested, and when Roberts failed to persuade him, she withdrew from the film, six weeks before shooting was due to begin. The production went into turnaround, and Zwick was unable to persuade other studios to take up the screenplay.  Eventually, Zwick got Miramax interested in the screenplay, but Miramax chose John Madden as director. Miramax boss Harvey Weinstein acted as producer, and persuaded Ben Affleck to take a small role as Ned Alleyn.  The film was considerably reworked after the first test screenings. The scene with Shakespeare and Viola in the punt was re-shot, to make it more emotional, and some lines were re-recorded to clarify the reasons why Viola had to marry Wessex. The ending was re-shot several times, until Stoppard eventually came up with the idea of Viola suggesting to Shakespeare that their parting could inspire his next play.  Among the locations used in the production were Hatfield House, Hertfordshire (for the fireworks scene), Broughton Castle, Oxfordshire (which played the role of the de Lesseps home), the beach at Holkham in Norfolk, the chapel at Eton College, Berkshire, and the Great Hall of Middle Temple, London.

What happened after that?
Zwick got Miramax interested in the screenplay, but Miramax chose John Madden as director.