In 1890, Nast published Thomas Nast's Christmas Drawings for the Human Race. He contributed cartoons in various publications, notably the Illustrated American, but was unable to regain his earlier popularity. His mode of cartooning had come to be seen as outdated, and a more relaxed style exemplified by the work of Joseph Keppler was in vogue. Health problems, which included pain in his hands which had troubled him since the 1870s, affected his ability to work.  In 1892, he took control of a failing magazine, the New York Gazette, and renamed it Nast's Weekly. Now returned to the Republican fold, Nast used the Weekly as a vehicle for his cartoons supporting Benjamin Harrison for president. The magazine had little impact and ceased publication seven months after it began, shortly after Harrison's defeat.  The failure of Nast's Weekly left Nast with few financial resources. He received a few commissions for oil paintings and drew book illustrations. In 1902, he applied for a job in the State Department, hoping to secure a consular position in western Europe. Although no such position was available, President Theodore Roosevelt was an admirer of the artist and offered him an appointment as the United States' Consul General to Guayaquil, Ecuador in South America. Nast accepted the position and traveled to Ecuador on July 1, 1902. During a subsequent yellow fever outbreak, Nast remained on the job, helping numerous diplomatic missions and businesses escape the contagion. He contracted the disease and died on December 7 of that year. His body was returned to the United States, where he was interred in the Woodlawn Cemetery in The Bronx, New York City.

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