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Mewtwo (Japanese: miyuutsu, Hepburn: Myutsu,  or ) is a fictional creature from Nintendo and Game Freak's Pokemon media franchise. Created by Ken Sugimori, it first appeared in the video games Pokemon Red and Blue and their sequels, and later appeared in various merchandise, spinoff titles, as well as animation adaptations of the franchise. Masachika Ichimura voiced the franchise's original Mewtwo character in Japanese, and the creature's younger self is voiced by Fujiko Takimoto in the Sound Picture Box: Mewtwo's Origin CD drama and Showtaro Morikubo in the anime adaptation. In English, Jay Goede voiced Mewtwo in Mewtwo Strikes Back and the Pokemon Live! musical.

Mewtwo has appeared as a central character in several books related to the Pokemon franchise, including novelizations of Mewtwo Strikes Back and Mewtwo Returns, both of which closely follow the events of the films. In December 1999, Viz Media published the children's picture book I'm Not Pikachu!: Pokemon Tales Movie Special, which featured children taking on traits of the characters from the film, including Mewtwo. In May 2001, Viz released a second children's book, Mewtwo's Watching You!, which featured a shy Mewtwo interestedly watching other Pokemon play.  In the manga series Pokemon Adventures, Team Rocket creates Mewtwo, but some of his DNA is placed inside of the Gym leader Blaine. Because of the DNA that they share, the two are unable to be separated for very long without becoming ill. Later, another Pokemon, Entei is able to break the bond between the two by removing the DNA in Blaine's arm, at which point Mewtwo leaves. It eventually helps the main character of the series, Red, fight against Team Rocket leader Giovanni and his Deoxys.  In 1998, Toshihiro Ono was asked to write a story detailing Mewtwo's origin to coincide with the release of Mewtwo Strikes Back. The 52-page comic, presented in the form of a flashback, was replaced midway by "The Birth of Mewtwo" animated short, resulting in little connection between Ono's work and the film. Regardless, it saw print as a side story for Pokemon: The Electric Tale of Pikachu in the July 1998 issue of CoroCoro Comic. In it, Mewtwo's creator Dr. Fuji takes on the role of a coach for the fully developed Pokemon, while his employer, Team Rocket, tests its abilities. Learning of a plan to mass-produce it as a weapon, Fuji approaches Mewtwo and tells it to destroy the lab and Fuji himself. Mewtwo refuses, stating it cannot harm the doctor, who it regards as its father. Once captured by Team Rocket, Fuji tells Mewtwo that he is honored by the statement, and is then killed. Angered by his death, Mewtwo destroys the lab and escapes. In the present, Mewtwo cries in its sleep as it dreams of the events.

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Mewtwo