Anna May Wong was born Wong Liu Tsong (meaning "yellow willow frost" respectively, though "yellow" being her family name can be considered functionless here semantically) on January 3, 1905, on Flower Street in Los Angeles, one block north of Chinatown, in an integrated community of Chinese, Irish, German and Japanese residents. She was the second of seven children born to Wong Sam Sing, owner of the Sam Kee Laundry, and his second wife Lee Gon Toy.  Wong's parents were second-generation Chinese Americans; her maternal and paternal grandparents had resided in the U.S. since at least 1855. Her paternal grandfather, A Wong Wong, was a merchant who owned two stores in Michigan Hills, a gold-mining area in Placer County. He had come from Chang On, a village near Taishan, Guangdong Province, China in 1853. Anna May's father spent his youth traveling between the U.S. and China, where he married his first wife and fathered a son in 1890. He returned to the U.S. in the late 1890s and in 1901, while continuing to support his family in China, he married a second wife, Anna May's mother. Anna May's older sister Lew Ying (Lulu) was born in late 1902, and Anna May in 1905, followed by five more children.  In 1910, the family moved to a neighborhood on Figueroa Street where they were the only Chinese on their block, living alongside mostly Mexican and Eastern European families. The two hills separating their new home from Chinatown helped Wong to assimilate into American culture. She attended public school with her older sister at first, but then, when the girls became the target of racial taunts from other students, they moved to a Presbyterian Chinese school. Classes were taught in English, but Wong attended a Chinese language school afternoons and on Saturdays.  About that same time, U.S. motion picture production began to relocate from the East Coast to the Los Angeles area. Movies were shot constantly in and around Wong's neighborhood. She began going to Nickelodeon movie theaters and quickly became obsessed with the "flickers", missing school and using lunch money to attend the cinema. Her father was not happy with her interest in films, feeling that it interfered with her studies, but Wong decided to pursue a film career regardless. At the age of nine, she constantly begged filmmakers to give her roles, earning herself the nickname "C.C.C." or "Curious Chinese Child". By the age of 11, Wong had come up with her stage name of Anna May Wong, formed by joining both her English and family names.

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