Gutfeld was born in San Mateo, California, the son of Jacqueline Bernice "Jackie" (nee Cauhape) and Alfred Jack Gutfeld. His father was of German Jewish-Catholic and Irish descent, while his mother was of Irish, French, and Mexican ancestry. He attended Junipero Serra High School and the University of California, Berkeley, graduating in 1987 with a B.A. in English.

After college he had an internship at The American Spectator, as an assistant to conservative writer R. Emmett Tyrrell. He then worked as a staff writer at Prevention magazine and in Emmaus, Pennsylvania, as an editor at various Rodale Press magazines. In 1995 he became a staff writer at Men's Health. He was promoted to editor in chief of Men's Health in 1999. A year later, he was replaced by David Zinczenko. Gutfeld then became editor in chief of Stuff, increasing circulation from 750,000 to 1.2 million during his tenure. In 2003 he hired several dwarfs to attend a conference of the "Magazine Publishers of America" on the topic of "buzz", with instructions to be as loud and annoying as possible. The stunt generated publicity but led to Gutfeld's being fired soon afterward; he was then made head of "brain development" at Dennis Publishing.  He edited Maxim magazine in the UK from 2004 to 2006. Gutfeld's contract expired without renewal after losses in readership under his tenure.  Gutfeld was one of the first posting contributors to The Huffington Post from its launch in 2005 until October 2008; frequent targets of his sarcasm included his colleagues Deepak Chopra, Cenk Uygur, Arianna Huffington, and Huffington Post bloggers. Many of his Huffington Post commentaries/blogs are available on its website. Gutfeld has his own blog site, The Daily Gut.  Beginning on February 5, 2007, Gutfeld hosted the hour-long Fox News Channel late-night program, Red Eye w/ Greg Gutfeld. From 2007 to 2013, Bill Schulz served as Gutfeld's "sidekick" and Andy Levy as the show's ombudsman. Schulz was Gutfeld's colleague at Stuff magazine and Levy was a fellow blogger at The Huffington Post. On July 11, 2011, Gutfeld became a co-host/panelist on the Fox News political opinion discussion program The Five. The program airs weekdays at 5 p.m. ET. Gutfeld left Red Eye in February 2015, to host a new weekend show on Fox News. He was replaced on Red Eye by Tom Shillue. In May 2015, it was announced that Gutfeld would be getting his own late-night show called The Greg Gutfeld Show, which debuted on May 31, at 10 p.m. ET.

Ask a question about this article.
How long did Red eye series last?