Norquist grew up in Weston, Massachusetts. He is the son of Carol (nee Lutz) and Warren Elliott Norquist (a vice president of Polaroid Corporation), and is of Swedish ancestry. His brother, David Norquist has served in senior posts in Republican administrations at both the United States Department of Defense and the United States Department of Homeland Security. Norquist became involved with politics at an early age when he volunteered for the 1968 Nixon campaign, assisting with get out the vote efforts.

Prior to the November 2012 election, 238 of 242 House Republicans and 41 out of 47 Senate Republicans had signed ATR's "Taxpayer Protection Pledge", in which the pledger promises to "oppose any and all efforts to increase the marginal income tax rate for individuals and business; and to oppose any net reduction or elimination of deductions and credits, unless matched dollar for dollar by further reducing tax rates."  The November 6, 2012 elections resulted in a decline in the number of Taxpayer Protection Pledge signatories in both the upper and lower houses of the 113th Congress: from 41 to 39 in the Senate, and from 238 to "fewer than ... 218" in the House of Representatives. According to journalist Alex Seitz-Wald, losses in the election by Norquist supporters and the "fiscal cliff" have emboldened and made more vocal critics of Norquist.  In November 2011, Senate Majority leader Harry Reid (D-NV) blamed Norquist's influence for the Joint Select Committee on Deficit Reduction's lack of progress, claiming that Congressional Republicans "are being led like puppets by Grover Norquist. They're giving speeches that we should compromise on our deficit, but never do they compromise on Grover Norquist. He is their leader." Since Norquist's pledge binds signatories to opposing deficit reduction agreements that include any element of increased tax revenue, some Republican deficit hawks now retired from office have stated that Norquist has become an obstacle to deficit reduction. Former Republican Senator Alan Simpson (R-WY), co-chairman of the National Commission on Fiscal Responsibility and Reform, has been particularly critical, describing Norquist's position as "[n]o taxes, under any situation, even if your country goes to hell."

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