Orci was born in Mexico City on July 20, 1973, to a Mexican father and a Cuban mother. His mother immigrated to the United States with her parents after Fidel Castro came to power. Orci grew up in Mexico, and moved with his family to the United States at the age of 10. He was raised in Texas, Los Angeles and Canada.

In April 2014, Orci and Kurtzman confirmed to Variety that they are no longer going to work together on film projects but will still collaborate on television. Kurtzman wanted to work on the Spider-Man film franchise, while Orci was linked to the directorial role for Star Trek 3. Orci confirmed later that year in July that he was not involved in the production of The Amazing Spider-Man 3 alongside Kurtzman. Orci and Kurtzman's K/O Paper Products continues to operate as a production company within CBS Television Studios, and has created the series Scorpion inspired by the life of Walter O'Brien for the 2014-15 season and Limitless was created for the 2015-16 season from the 2011 film.  Prior to the split of Kurtzman and Orci, the duo were lined up to write the third film in the new Star Trek series. In May 2014, Skydance and Paramount Pictures announced that Orci was to direct the third installment of the Star Trek reboot franchise, after Abrams moved on to direct Star Wars: The Force Awakens. This would have marked Orci's directorial debut, and he was to write the script alongside co-writers JD Payne and Patrick McKay. Due to his commitment to Star Trek 3, he dropped out of a new Power Rangers film, for which he would have been executive producer. But on December 5, it was announced he would no longer be directing the Star Trek film. He remains credited as a producer on the film, and was replaced by Doug Jung and cast member Simon Pegg as the script writers after Orci's initial script was dropped. Orci was replaced as director by Justin Lin, who had previously directed films in The Fast and the Furious franchise.  Orci created Matador with the idea that the main character would be a "soccer player by day who is a spy by night", and called him a "Latin James Bond". The series was broadcast on the El Rey Network created by Robert Rodriguez. It was renewed for a second season shortly before the pilot was broadcast, which had been directed by Rodriguez. But following the production of the first season, the series was cancelled despite the earlier renewal. This decision was blamed on poor international sales.

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