Rose appeared on the first episode of Talkin' 'Bout Your Generation, representing Generation Y alongside comedian Josh Thomas. She was selected in 2008 to act in the Australian comedy film Suite for Fleur. She also appeared alongside Christina Ricci and Jack Thompson in the 2013 film Around the Block.  Rose credits her 2014 short film Break Free, which she produced herself, for the success of her acting career. In an interview with Variety, she describes how she was not able to get a manager, agent, or audition, so she decided to create short films "as a way of being able to give myself something to do and to study my craft." The film went viral, getting millions of views in a short period of time.  In 2015, Rose joined the Orange Is the New Black cast in Season 3. Rose played inmate Stella Carlin, "whose sarcastic sense of humor and captivating looks quickly draw the attention of some of Litchfield's inmates." Rose's performance was generally well-received by the public. She was also cast in a guest role, as the service robot Wendy, in the science fiction series Dark Matter.  In 2016, Rose and Tom Felton would lend their voices in the animated title Sheep and Wolves, with Rose as his fiance Bianca. On 3 August, it was announced that Rose has been cast for the Warner Bros. film Meg, a shark epic based on the novel of the same name, alongside Jason Statham; the film is set for a 2018 release.  In 2016 and 2017, Rose appeared in three action film sequels, xXx: Return of Xander Cage, alongside Vin Diesel, Resident Evil: The Final Chapter as Abigail, and John Wick: Chapter 2, alongside Keanu Reeves; she also played a musical rival in the comedy Pitch Perfect 3, which was released in December 2017. On 20 June, it was confirmed that xXx: Return of Xander Cage Sequel 'xXx4' is in the works. It was also announced that Rose will be starring in the action comedy Three Sisters.

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