Problem: Cast are an English rock band from Liverpool, formed in 1992 by John Power (vocals, guitar) and Peter Wilkinson (backing vocals, bass) after Power left The La's and Wilkinson's former band Shack had split. Following early line-ups with different guitarists and drummers, Liam "Skin" Tyson (guitar) and Keith O'Neill (drums) joined Cast in 1993. Emerging from the Britpop movement of the mid-1990s, Cast signed to Polydor Records and their debut album All Change (1995) became the highest selling debut album for the label. Further commercial success continued with the albums Mother Nature Calls (1997) and Magic Hour (1999), however a departure in sound on the band's fourth album Beetroot (2001) was met by a poor critical and commercial reaction and contributed to the band's split two weeks after its release.

John Power was previously the bass player, backing vocalist and only constant member along with Lee Mavers in The La's. He left the band on 13 December 1991 after becoming frustrated with the ever-increasing number of aborted studio sessions, having played essentially the same set of songs since 1986 and emerging as a songwriter in his own right. Power later commented that by that point he was more interested in his own songs "than anyone else's".  Having switched from bass to rhythm guitar whilst residing at Brucklay House - a near derelict squat in Mossley Hill, where the seeds of legendary dance label 3 Beat Records were sown, Power began jamming with friends and with an ever-changing line-up began to form Cast. The first addition to the band was ex-Shack bassist Peter Wilkinson who had seen Power performing acoustically at a free festival in Liverpool, and who Power had seen around town.". Embryonic lineups of the band, featuring several guitarists including Ged Malley, ex-La's members Barry Sutton and Cammy and drummer Russell Brady started gigging in mid 1992 and supported the likes of Pele and The Stairs. Power would later state that he was never happy with these lineups. Unhappy with the band and the demos recorded with Who sound engineer Bob Pridden, he split the band up and extricated himself from his Go! Discs contract in Summer 1993, with whom he was still signed to following his departure from The La's and set about forming a new lineup with Wilkinson.  The first new member to be recruited was Keith O'Neill who had previously played in The Empty Hours, The Windmills and Tommy Scott's pre-Space band The Australians and who Power had seen playing in local band The Windmills, fronted by Howie Payne later of The Stands and then guitarist Liam 'Skin' Tyson, who Wilkinson knew from college and had previously played in Pyramid Dream. When approached to join the band, Tyson initially declined as he had sold all of his musical equipment to teach canoeing at an outdoor centre in Alston in Cumbria. Tyson, who witnessed one of the band's early London shows and commented that "John had these songs, but not the band", joined the band in November 1993 and the new lineup played their first gig in Hull in January 1994. Within months the band secured high-profile support slots with Elvis Costello on two UK tours, including 2 nights at the Royal Albert Hall and Oasis. It was during the tour with Oasis that Polydor head of A&R Paul Adam, surprised that the band had not already been snapped up, approached the band to sign them. The band signed to Polydor on 13 December 1994, three years to the day that Power left The La's.

who are the band members?

Answer with quotes: The first addition to the band was ex-Shack bassist Peter Wilkinson


Problem: Tu Youyou (Chinese: Tu You You ; pinyin: Tu Youyou; born 30 December 1930) is a Chinese pharmaceutical chemist and educator. She is best known for discovering artemisinin (also known as qinghaosu) and dihydroartemisinin, used to treat malaria, which has saved millions of lives.

Tu Youyou carried on her work in the 1960s and 70s during China's Cultural Revolution, when scientists were denigrated as one of the nine black categories in society according to Maoist theory (or possibly that of the Gang of Four).  In 1967, during the Vietnam War, Ho Chi Minh, the leader of North Vietnam, which was at war against South Vietnam and the United States, asked Chinese Premier Zhou Enlai for help in developing a malaria treatment for his soldiers trooping down the Ho Chi Minh trail, where a majority came down with a form of malaria which is resistant to chloroquine. Because malaria was also a major cause of death in China's southern provinces including Hainan, Yunnan, Guangxi, and Guangdong, Zhou Enlai convinced Mao Zedong to set up a secret drug discovery project, named Project 523 after its starting date, 23 May 1967. Upon joining the project unit, Tu was initially sent to Hainan where she studied patients who had been infected with the disease. During the time she spent there, her husband was banished to the countryside, meaning that her daughter had to be entrusted to a nursery in Beijing.  Scientists worldwide had screened over 240,000 compounds without success. In 1969, Tu Youyou, then 39 years old, had an idea of screening Chinese herbs. She first investigated the Chinese medical classics in history, visiting practitioners of traditional Chinese medicine all over the country on her own. She gathered her findings in a notebook called A Collection of Single Practical Prescriptions for Anti-Malaria. Her notebook summarized 640 prescriptions. Her team also screened over 2,000 traditional Chinese recipes and made 380 herbal extracts, which were tested on mice.  One compound was effective, sweet wormwood (Artemisia annua), which was used for "intermittent fevers," a hallmark of malaria. As Tu also presented at the project seminar, its preparation was described in a 1,600-year-old text, in a recipe titled, "Emergency Prescriptions Kept Up One's Sleeve". At first, it didn't work, because they extracted it with traditional boiling water. Tu Youyou discovered that a low-temperature extraction process could be used to isolate an effective antimalarial substance from the plant; Tu says she was influenced by a traditional Chinese herbal medicine source, The Handbook of Prescriptions for Emergency Treatments, written in 340 by Ge Hong, which states that this herb should be steeped in cold water. This book contained the useful reference to the herb: "A handful of qinghao immersed with two litres of water, wring out the juice and drink it all." After rereading the recipe, Tu realised the hot water had already damaged the active ingredient in the plant; therefore she proposed a method using low-temperature ether to extract the effective compound instead. The animal tests showed it was completely effective in mice and monkeys.  Furthermore, Tu volunteered to be the first human subject. "As head of this research group, I had the responsibility" she said. It was safe, so she conducted successful clinical trials with human patients. Her work was published anonymously in 1977. In 1981, she presented the findings relating to artemisinin at a meeting with the World Health Organization.

Was malaria a problem in China?

Answer with quotes:
Tu volunteered to be the first human subject.