A synthesizer (often abbreviated as synth, also spelled synthesiser) is an electronic musical instrument that generates electric signals that are converted to sound through instrument amplifiers and loudspeakers or headphones. Synthesizers may either imitate traditional musical instruments like piano, Hammond organ, flute, vocals; natural sounds like ocean waves, etc.; or generate novel electronic timbres. They are often played with a musical keyboard, but they can be controlled via a variety of other input devices, including music sequencers, instrument controllers, fingerboards, guitar synthesizers, wind controllers, and electronic drums. Synthesizers without built-in controllers are often called sound modules, and are controlled via USB, MIDI or CV/gate using a controller device, often a MIDI keyboard or other controller.

In the 1970s, electronic music composers such as Jean Michel Jarre, Vangelis and Isao Tomita, released successful synthesizer-led instrumental albums. Over time, this helped influence the emergence of synthpop, a subgenre of new wave, from the late 1970s to the early 1980s. The work of German krautrock bands such as Kraftwerk and Tangerine Dream, British acts such as John Foxx, Gary Numan and David Bowie, African-American acts such as George Clinton and Zapp, and Japanese electronic acts such as Yellow Magic Orchestra and Kitaro, were influential in the development of the genre. Gary Numan's 1979 hits "Are 'Friends' Electric?" and "Cars" made heavy use of synthesizers. OMD's "Enola Gay" (1980) used distinctive electronic percussion and a synthesized melody. Soft Cell used a synthesized melody on their 1981 hit "Tainted Love". Nick Rhodes, keyboardist of Duran Duran, used various synthesizers including the Roland Jupiter-4 and Jupiter-8.  Chart hits include Depeche Mode's "Just Can't Get Enough" (1981), The Human League's "Don't You Want Me" and Giorgio Moroder's Take My Breath Away (1986) for Berlin. Other notable synthpop groups included New Order, Visage, Japan, Men Without Hats, Ultravox, Spandau Ballet, Culture Club, Eurythmics, Yazoo, Thompson Twins, A Flock of Seagulls, Heaven 17, Erasure, Soft Cell, Pet Shop Boys, Bronski Beat, Kajagoogoo, ABC, Naked Eyes, Devo, and the early work of Tears for Fears and Talk Talk. Giorgio Moroder, Brian Eno, Phil Collins, Howard Jones, Stevie Wonder, Peter Gabriel, Thomas Dolby, Kate Bush, Enya, Mike Oldfield, Donal Lunny, Frank Zappa and Todd Rundgren all made use of synthesizers.  The synthesizer became one of the most important instruments in the music industry.

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Over time, this helped influence the emergence of synthpop, a subgenre of new wave, from the late 1970s to the early 1980s.