Drusilla, or Dru, is a fictional character created by Joss Whedon and David Greenwalt for the American television series, Buffy the Vampire Slayer and Angel. The character is portrayed by American actress Juliet Landau. Drusilla is introduced alongside her lover Spike (James Marsters) in the second season of Buffy the Vampire Slayer to serve as new antagonists to the series' heroine, vampire Slayer Buffy Summers (Sarah Michelle Gellar) and alongside Darla (Julie Benz) and Wolfram & Hart as the main antagonist of the second season of Angel. In contrast to the series' previous central villain, the ancient and ceremonious Master (Mark Metcalf), Spike and Dru were introduced as a more unconventional but equally dangerous pair of vampires.

Actress Juliet Landau said that when she first received the script, it indicated that Drusilla's accent could be British or American. Landau felt Drusilla "should really be Cockney, especially with the whole Sid and Nancy analogy." Though she never considered portraying Drusilla with a Southern American accent, as James Marsters had considered for Spike, she notes that invited comparisons with Blanche DuBois would also have been interesting.  Drusilla's madness is exhibited in her often-strange dialogue, which is peppered with non sequiturs like "Spike, do you love my insides? All the parts you can't see?" Her behavior is girlish, accompanied by a dark, ironic twist. For instance, when she is happy, she will squeal and laugh like a young child, but she is happiest when committing torture, hunting humans, or witnessing mass destruction. She has a fondness for china dolls but keeps them blindfolded or gagged. She also loves flowers and cute animals, but is not sane enough to care for them; as she says, "Do you like daisies? I plant them but they always die. Everything I put in the ground withers and dies." She even goes so far as to own a Pekingese puppy. She speaks in a soft, mellow voice which contrasts with her dialogue. All of "white hats" (both Scoobies and Angel's Investigations) are doubtful about how to deal with her, originally an innocent victim. Mostly and obviously Angel.  Drusilla's costumes were initially intended to be a "cross between a Victorian period look and the Kate Moss heroin chic fashion look," says Landau.

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She also loves flowers and cute animals, but is not sane enough to care for them;