Winchell was born Paul Wilchinsky in New York City on December 21, 1922, to Solomon Wilchinsky and Clara Fuchs. His father was a tailor; his grandparents were Jewish immigrants from Russian Poland and Austria-Hungary. Winchell's initial ambition was to become a doctor, but the Depression wiped out any chance of his family's ability to afford medical school tuition. At age 13, he contracted polio; while recovering, he happened upon a magazine advertisement offering a ventriloquism kit for ten cents.

Winchell was a pre-med student at Columbia University. He graduated from The Acupuncture Research College of Los Angeles in 1974, and became an acupuncturist. He also worked as a medical hypnotist at the Gibbs Institute in Hollywood. He developed over 30 patents in his lifetime. He invented an artificial heart with the assistance of Dr. Henry Heimlich, inventor of the Heimlich Maneuver, and held an early but not the first U.S. patent for such a device. The University of Utah developed a similar apparatus around the same time, but when they tried to patent it, Winchell's heart was cited as prior art. The university requested that Winchell donate the heart to the University of Utah, which he did.  There is some debate as to how much of Winchell's design Dr. Robert Jarvik used in creating Jarvik's artificial heart. Dr. Heimlich states, "I saw the heart, I saw the patent and I saw the letters. The basic principle used in Winchell's heart and Jarvik's heart is exactly the same."  Jarvik denies that any of Winchell's design elements were incorporated into the device he fabricated for humans -- the Jarvik-7, which was successfully implanted into Barney Clark in 1982.  Winchell established more medical patents while working on projects for the Leukemia Society (now known as the Leukemia & Lymphoma Society) and the American Red Cross. Other devices which he invented and patented include a disposable razor, a blood plasma defroster, a flameless cigarette lighter, an "invisible" garter belt, a fountain pen with a retractable tip, and battery-heated gloves.

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