Sean John Combs was born on November 4, 1969 in Manhattan's Harlem neighborhood in New York City, and was raised in Mount Vernon, New York. His mother, Janice (Smalls), was a model and teacher's assistant, and his father, Melvin Earl Combs, served in the U.S. Air Force and was an associate of convicted New York drug dealer Frank Lucas. At age 33, Melvin was shot to death while sitting in his car on Central Park West, when Combs was 2 years old. Combs graduated from the Roman Catholic Mount Saint Michael Academy in 1987.

In 1998, Combs started a clothing line, Sean John. It was nominated for the Council of Fashion Designers of America (CFDA) award for Menswear Designer of the Year in 2000, and won in 2004. California billionaire Ronald Burkle invested $100 million into the company in 2003.  Also in 2003, the National Labor Committee revealed that factories producing the clothing in Honduras were violating Honduran labor laws. Among the accusations were that workers were subjected to body searches and involuntary pregnancy tests. Bathrooms were locked and access tightly controlled. Employees were forced to work overtime and were paid sweatshop wages. Charles Kernaghan of the National Labor Committee told The New York Times that "Sean Puff Daddy obviously has a lot of clout, he can literally do a lot overnight to help these workers."  Combs responded with an extensive investigation, telling reporters "I'm as pro-worker as they get". On February 14, 2004, Kernaghan announced that improvements had been implemented at the factory, including adding air conditioning and water purification systems, firing the most abusive supervisors, and allowing the formation of a labor union. In late 2006, the department store Macy's removed Sean John jackets from their shelves when they discovered that the clothing was made using raccoon dog fur. Combs had not known the jackets were made with dog fur, but as soon as he was alerted, he had production stopped.  In November 2008, Combs added a men's perfume called "I Am King" to the Sean John brand. The fragrance, dedicated to Barack Obama, Muhammad Ali, and Martin Luther King, featured model Bar Refaeli in its advertisements. In early 2016, Sean John introduced the brand's GIRLS collection.

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