In September 2007, Between the Buried and Me released their fourth studio album (fifth if including The Anatomy Of), Colors. Band members called it "a 65 minute opus of non stop pummeling beautiful music... we have described this release as 'new wave polka grunge'." The band also described the album as "adult contemporary progressive death metal".  In September 2007, after the release of Colors, the band went on tour with Animosity and Horse the Band. Giant (now known as BraveYoung) also supported their shows in the USA. The run concluded with their November 4 appearance at the Saints and Sinners Fest in Asbury Park, New Jersey. In December 2007, they again embarked on a headlining tour, supported by August Burns Red and Behold... The Arctopus. The band were also the main support on The Dillinger Escape Plan's 2008 UK tour. Between the Buried and Me were one of the acts that took part at "Progressive Nation '08", the first in what became an annual progressive music festival, also featuring Dream Theater, Opeth, and 3.  Starting in summer 2008 and continuing in the fall, they performed as a supporting act for Children of Bodom's US headlining tour, alongside The Black Dahlia Murder. In early December 2008, they went on a short 4-show tour around the Carolinas and Georgia (US) with other Carolina-based bands, such as He Is Legend, Advent, and Nightbear. Between the Buried and Me finished a month-long tour of Australia on January 9 with headliners Bleeding Through, As Blood Runs Black, In Trenches and The Abandonment. In September 2009, Between the Buried and Me performed a Canadian Tour with Killswitch Engage and In Flames co-headlining, along with the support of Protest the Hero.  On May 31, 2009, the group went into the studio to record their fifth album (sixth if including The Anatomy Of), The Great Misdirect. They released the single "Obfuscation" on September 29 and the album on October 27.

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Band members called it "a 65 minute opus of non stop pummeling beautiful music...