Despite little mainstream airplay, several Skinny Puppy releases have charted in North America and Europe, and their influence on industrial and electronic music is considerable. Widely considered originators of a unique sound and live performance style, Skinny Puppy are also known as pioneers of industrial rock and electro-industrial, genres in which they may be seen to have spawned "a litter of like-minded bands". Their influence extends from independent acts like Tin Omen, to industrial rock stars Nine Inch Nails, who opened for Skinny Puppy for a short time on their 1988 North American tour. Trent Reznor also acknowledged that Skinny Puppy's "Dig It" inspired the very first Nine Inch Nails track written, "Down in It". Canadian synthpop artist Grimes includes Skinny Puppy as an influence on her music, having grown up in Vancouver's industrial music scene. Sara Taylor of the EBM group Youth Code has said that the song "Worlock" was "one of the most influential songs" she had ever heard. Other artists that have been impacted by Skinny Puppy's music include Marilyn Manson, Chester Bennington, 3Teeth, Foals vocalist Yannis Philippakis, Al Jourgensen, X Marks the Pedwalk, Wumpscut, Haujobb, Orgy, Filter, Front Line Assembly, Orphx, Crystal Castles, and Mayhem vocalist Attila Csihar.  The band inspired a tribute album, Hymns of the Worlock: A Tribute to Skinny Puppy published by Cleopatra Records, which features groups such as Crocodile Shop and The Electric Hellfire Club. Skinny Puppy's remix album Remix Dystemper, published by Nettwerk Productions, includes contributions from a wide array of musicians such as electronic music DJ Josh Wink, Guru, KMFDM, Deftones, and former Nine Inch Nails drummer Chris Vrenna. Vrenna's solo project, Tweaker, opened for Skinny Puppy during their 2004 North American tour. Danny Carey from Tool and Wayne Static of Static-X provided drums and backup vocals, respectively, for the song "Use Less" from The Greater Wrong of the Right.  Ogre worked with KMFDM on several occasions, touring with them in 1997 and providing vocals on the song "Torture" from their album Symbols (the song also features production from Dave Ogilvie) as well as for the songs "That's All" and "Full Worm Garden" from 1999's Adios. Skinny Puppy also provided a remix for the Motley Crue song "Hooligan's Holiday"; Nikki Sixx reported that the band "just dumped the whole song in the computer and went off".  Skinny Puppy's music has been included in the soundtracks of films such as Bad Influence, An American Werewolf in Paris, The Blair Witch Project, Underworld, and Saw II, among others. The group was given a brief role as the "gang of goons" in the 1995 dark comedy film The Doom Generation. The 1996 Video Game Descent II included original music from Ogre and Mark Walk, while the 2014 PlayStation exclusive LittleBigPlanet 3 featured the song "Rodent" from the album Rabies.  While discussing the possibility of Nine Inch Nails being inducted into the Rock and Roll Hall of Fame, Richard Patrick of the band Filter remarked "what about Skinny Puppy?", going on to say that while Nine Inch Nails is the more famous of the two, Skinny Puppy were one of the first groups to craft "scary and mean" industrial music.

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