"Hit 'Em Up" is a diss song by rap artist 2Pac featuring his group the Outlawz. It is the B-side to the single "How Do U Want It", released on June 4, 1996. The song's lyrics contain vicious insults to several East Coast rappers, chief among them, Shakur's former friend turned rival, The Notorious B.I.G., also known as Biggie Smalls.

The music video for "Hit 'Em Up" was filmed in a warehouse off Slauson Avenue near Fox Hills Mall in Los Angeles in May 1996. It was filmed by the production company Look Hear Productions. Shakur raps in a white room with The Outlawz, as well as in purple-caged room and a black room with bullet holes in the background. TV monitors in the background show clips of Shakur, Puffy, and Biggie Smalls, and even clips from the video "Made Niggaz." The video featured actors who were recalled from their prior roles in the music video for "2 of Amerikaz Most Wanted" to impersonate some of those who were attacked in "Hit 'Em Up." This included Biggie, whose stand-in stares dully into the camera and sports a Kangol and jacket, similar to one Biggie would wear. During the moments where Shakur raps about his claimed affair with Evans, the Biggie impersonator crouches near the camera while Shakur yells in his face. Puffy is also impersonated, appearing with a high-top fade and leaning towards the camera, lowering and raising his sunglasses.  During the shooting of the video, Shakur was engaged in an argument with someone, who was heard telling him "You'll get shot." His armed bodyguard assured him that he had nothing to worry about. He also broke up a fight involving his friend Muta during the filming, and fired a production assistant on set. The assistant was answering Shakur's pager and returning his personal calls without his consent. Many callers were confused or angry that a female assistant was answering Shakur's calls. The assistant had mistakenly lost the pager, and with Shakur already growing wary of her, fired her for that reason.  Like the song, the video for "Hit 'Em Up" has also been called "infamous". The pro-West Coast track's music video featured the members crushing buildings in Manhattan, which was already done in another pro-West Coast music video for "New York, New York" by Tha Dogg Pound earlier. The music video for "Hit 'Em Up" can be found on Tupac: Live at the House of Blues DVD.

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