Jarmusch was born January 22, 1953, in Cuyahoga Falls, Ohio, the middle of three children of middle-class suburbanites. His mother, of German and Irish descent, had been a reviewer of film and theatre for the Akron Beacon Journal before marrying his father, a businessman of Czech and German descent who worked for the B.F. Goodrich Company. She introduced Jarmusch to the world of cinema by leaving him at a local cinema to watch matinee double features such as Attack of the Crab Monsters and Creature From the Black Lagoon while she ran errands. The first adult film he recalls seeing was the 1958 cult classic Thunder Road, the violence and darkness of which left an impression on the seven-year-old Jarmusch.

Jarmusch's final year university project was completed in 1980 as Permanent Vacation, his first feature film. It had its premiere at the International Filmfestival Mannheim-Heidelberg (formerly known as Filmweek Mannheim) and won the Josef von Sternberg Award. It was made on a shoestring budget of around $12,000 in misdirected scholarship funds and shot by cinematographer Tom DiCillo on 16 mm film. The 75 minute quasi-autobiographical feature follows an adolescent drifter (Chris Parker) as he wanders around downtown Manhattan.  The film was not released theatrically, and did not attract the sort of adulation from critics that greeted his later work. The Washington Post staff writer Hal Hinson would disparagingly comment in an aside during a review of Jarmusch's Mystery Train (1989) that in the director's debut, "the only talent he demonstrated was for collecting egregiously untalented actors". The bleak and unrefined Permanent Vacation is nevertheless one of the director's most personal films, and established many of the hallmarks he would exhibit in his later work, including derelict urban settings, chance encounters, and a wry sensibility.  Jarmusch's first major film, Stranger Than Paradise, was produced on a budget of approximately $125,000 and released in 1984 to much critical acclaim. A deadpan comedy recounting a strange journey of three disillusioned youths from New York through Cleveland to Florida, the film broke many conventions of traditional Hollywood filmmaking. It was awarded the Camera d'Or at the 1984 Cannes Film Festival as well as the 1985 National Society of Film Critics Award for Best Film, and became a landmark work in modern independent film.

Did this film finally attract other critics?
The Washington Post staff writer Hal Hinson would disparagingly comment in an aside during a review of Jarmusch's Mystery Train (1989)