Answer the question at the end by quoting:

Sir Alexander Fleming  (6 August 1881 - 11 March 1955) was a Scottish physician, microbiologist, and pharmacologist. His best-known discoveries are the enzyme lysozyme in 1923 and the world's first antibiotic substance benzylpenicillin (Penicillin G) from the mould Penicillium notatum in 1928, for which he shared the Nobel Prize in Physiology or Medicine in 1945 with Howard Florey and Ernst Boris Chain. He wrote many articles on bacteriology, immunology, and chemotherapy. Fleming was knighted for his scientific achievements in 1944.
When I woke up just after dawn on September 28, 1928, I certainly didn't plan to revolutionise all medicine by discovering the world's first antibiotic, or bacteria killer. But I suppose that was exactly what I did.  By 1927, Fleming had been investigating the properties of staphylococci. He was already well-known from his earlier work, and had developed a reputation as a brilliant researcher, but his laboratory was often untidy. On 3 September 1928, Fleming returned to his laboratory having spent August on holiday with his family. Before leaving, he had stacked all his cultures of staphylococci on a bench in a corner of his laboratory. On returning, Fleming noticed that one culture was contaminated with a fungus, and that the colonies of staphylococci immediately surrounding the fungus had been destroyed, whereas other staphylococci colonies farther away were normal, famously remarking "That's funny". Fleming showed the contaminated culture to his former assistant Merlin Price, who reminded him, "That's how you discovered lysozyme." Fleming grew the mould in a pure culture and found that it produced a substance that killed a number of disease-causing bacteria. He identified the mould as being from the Penicillium genus, and, after some months of calling it "mould juice", named the substance it released penicillin on 7 March 1929. The laboratory in which Fleming discovered and tested penicillin is preserved as the Alexander Fleming Laboratory Museum in St. Mary's Hospital, Paddington.  He investigated its positive anti-bacterial effect on many organisms, and noticed that it affected bacteria such as staphylococci and many other Gram-positive pathogens that cause scarlet fever, pneumonia, meningitis and diphtheria, but not typhoid fever or paratyphoid fever, which are caused by Gram-negative bacteria, for which he was seeking a cure at the time. It also affected Neisseria gonorrhoeae, which causes gonorrhoea, although this bacterium is Gram-negative.  Fleming published his discovery in 1929, in the British Journal of Experimental Pathology, but little attention was paid to his article. Fleming continued his investigations, but found that cultivating penicillium was quite difficult, and that after having grown the mould, it was even more difficult to isolate the antibiotic agent. Fleming's impression was that because of the problem of producing it in quantity, and because its action appeared to be rather slow, penicillin would not be important in treating infection. Fleming also became convinced that penicillin would not last long enough in the human body (in vivo) to kill bacteria effectively. Many clinical tests were inconclusive, probably because it had been used as a surface antiseptic. In the 1930s, Fleming's trials occasionally showed more promise, and he continued, until 1940, to try to interest a chemist skilled enough to further refine usable penicillin. Fleming finally abandoned penicillin, and not long after he did, Howard Florey and Ernst Boris Chain at the Radcliffe Infirmary in Oxford took up researching and mass-producing it, with funds from the U.S. and British governments. They started mass production after the bombing of Pearl Harbor. By D-Day in 1944, enough penicillin had been produced to treat all the wounded in the Allied forces.

were there any problems?

affected bacteria such as staphylococci and many other Gram-positive pathogens that cause scarlet fever, pneumonia, meningitis and diphtheria, but not typhoid fever



Answer the question at the end by quoting:

Helen Folasade Adu was born on 16 January 1959 in Ibadan, Oyo State, Nigeria. Her middle name, Folasade, means "honour confers a crown". Her parents, Adebisi Adu, a Nigerian lecturer in economics of Yoruba background, and Anne Hayes, an English district nurse, met in London, married in 1955 and moved to Nigeria. Her parents separated, however, and Anne Hayes returned to England, taking four-year-old Sade and older brother Banji with her to live with their grandparents near Colchester, Essex.
In late 1985, the band released their second album, Promise, which peaked at number one in both the UK and the US and became the band's first album to reach number one on the US Billboard 200. The album topped the chart in 1986 and spent two weeks at the peak position. Eventually, the album went on to sell four million copies in the region and was certified four times platinum by the Recording Industry Association of America (RIAA). The album spawned two singles "Never as Good as the First Time" and "The Sweetest Taboo," the latter of which was released as the album's lead single and stayed on the US Hot 100 for six months. "The Sweetest Taboo" peaked at number five on the US Billboard Hot 100, number one on the US adult Contemporary chart, and number three on the US Hot R&B/Hip-Hop Singles & Tracks. Sade was so popular that some radio stations reinstated the '70s practice of playing album tracks, adding "Is It a Crime" and "Tar Baby" to their playlists. The following year, 1986, the band won a Grammy Award for Best New Artist.  In 1986, Sade made her acting debut in Absolute Beginners, a film adapted from the Colin MacInnes book of the same name about life in late-1950s London. Sade played the role of Athene Duncannon and lent her vocals to the film's accompanying soundtrack. The film was screened out of competition at the 1986 Cannes Film Festival and grossed PS1.8 million in the UK. Sade's third album, Stronger Than Pride, was released on 3 May 1988, and like Sade's previous album became a commercial success and certified three times platinum in the US. The album was popularized by four singles, most notably the album's second single "Paradise", which peaked at number 16 on the US Billboard Hot 100 and peaked at number one on the US Billboard Hot R&B/Hip-Hop Songs, becoming the band's first single to do so.  Love Deluxe was released as the band's fourth studio album on 26 October 1992. The album peaked at number three on the US Billboard 200 and has sold 3.4 million copies in the United States. The album was later certified four times platinum by the RIAA for shipments of four million copies. The album was also commercially successful elsewhere, reaching number-one in France, and reaching the top ten in New Zealand, Sweden, Switzerland and the UK. The album went on to be certified gold in the United Kingdom. In November 1994, the group released their first compilation album, The Best of Sade. The album was another top ten hit in both the United Kingdom and the United States, certified platinum and four times platinum, respectively. The compilation album included material from Sade's previous albums, as well as a cover version of "Please Send Me Someone to Love" (1950), originally by Percy Mayfield.

What happened in 1988?
Sade's third album, Stronger Than Pride, was released on 3 May 1988,