Groening was born on February 15, 1954 in Portland, Oregon, the middle of five children (older brother Mark and sister Patty were born in 1950 and 1952, while the younger sisters Lisa and Maggie in 1956 and 1958, respectively). His Norwegian American mother, Margaret Ruth (nee Wiggum; March 23, 1919 - April 22, 2013), was once a teacher, and his German Canadian father, Homer Philip Groening (December 30, 1919 - March 15, 1996), was a filmmaker, advertiser, writer and cartoonist. Homer, born in Main Centre, Saskatchewan, Canada, grew up in a Mennonite, Plautdietsch-speaking family.

After spending a few years researching science fiction, Groening got together with Simpsons writer/producer David X. Cohen (known as David S. Cohen at the time) in 1997 and developed Futurama, an animated series about life in the year 3000. By the time they pitched the series to Fox in April 1998, Groening and Cohen had composed many characters and storylines; Groening claimed they had gone "overboard" in their discussions. Groening described trying to get the show on the air as "by far the worst experience of [his] grown-up life." The show premiered on March 28, 1999. Groening's writing credits for the show are for the premiere episode, "Space Pilot 3000" (co-written with Cohen), "Rebirth" (story) and "In-A-Gadda-Da-Leela" (story).  After four years on the air, the show was canceled by Fox. In a situation similar to Family Guy, however, strong DVD sales and very stable ratings on Adult Swim brought Futurama back to life. When Comedy Central began negotiating for the rights to air Futurama reruns, Fox suggested that there was a possibility of also creating new episodes. When Comedy Central committed to sixteen new episodes, it was decided that four straight-to-DVD films - Bender's Big Score (2007), The Beast with a Billion Backs (2008), Bender's Game (2008) and Into the Wild Green Yonder (2009) - would be produced.  Since no new Futurama projects were in production, the movie Into the Wild Green Yonder was designed to stand as the Futurama series finale. However, Groening had expressed a desire to continue the Futurama franchise in some form, including as a theatrical film. In an interview with CNN, Groening said that "we have a great relationship with Comedy Central and we would love to do more episodes for them, but I don't know... We're having discussions and there is some enthusiasm but I can't tell if it's just me". Comedy Central commissioned an additional 26 new episodes, and began airing them in 2010. The show continued in to 2013, before Comedy Central announced in April 2013 that they would not be renewing it beyond its seventh season. The final episode aired on September 4, 2013.

Did he do anything besides write?
Groening and Cohen had composed many characters and storylines;