Danzig was born Glenn Allen Anzalone, the third of four sons born to a Protestant family of Italian, German, and Scottish heritage in Lodi, New Jersey. His father was a television repairman and a United States Marine Corps veteran of World War II and the Korean War. His mother worked at a record store. Danzig and his family also spent some time living in Revere, Massachusetts.

In the mid-1970s, Danzig started the Misfits, releasing the band's records through his own label, (originally known as Blank, then later as Plan 9). Danzig had attempted to get the Misfits signed to several record labels, only to be told that he would never have a career in music. The impetus for the band's name comes from Marilyn Monroe's last film, combined with Danzig considering himself to be a "social misfit." In October 1983, after releasing several singles and three albums, and gaining a small underground following, Danzig disbanded the Misfits due to increasing animosity among the band members and his dissatisfaction with their musical abilities. Danzig explained his decision: "It was difficult for me to work with those guys, because they weren't prepared to put in the hours practicing. I wanted to move things forward, and they didn't seem to have the same outlook. So it was time for me to move on."  After the Misfits, he began work on a new band project: Samhain. The origins of Samhain began when Danzig started rehearsing with Eerie Von, formerly of Rosemary's Babies. Danzig took the name of the band from the ancient Celtic New Year, which influenced the evolution of the modern Halloween. Initially Samhain was conceived as a punk rock "super group". The band briefly featured members of Minor Threat and Reagan Youth, who contributed to Samhain's 1984 debut, Initium. The band then settled with a lineup consisting of Eerie Von on bass, Damien on guitar, and Steve Zing on drums (later replaced by London May). In 1985 the Unholy Passion EP was released, followed by November-Coming-Fire in 1986.  Samhain eventually began to attract the interest of major labels including Epic and Elektra. Rick Rubin, music producer and head of the Def American label, would see the band perform at the 1986 New Music Seminar, on the advice of then-Metallica bassist Cliff Burton. Danzig has credited both Burton and Metallica frontman James Hetfield with helping to raise awareness about his music: "I first met them at a Black Flag gig, and then we became kinda friends. We'd often bump into each other on the road...James and Cliff helped to spread the word about me, and I was very grateful to them."

Did misfits release any albums?
After the Misfits, he began work on a new band project: Samhain.