Question:
O'Neill was born in a hotel, the Barrett House, at Broadway and 43rd Street, on what was then Longacre Square (now Times Square). A commemorative plaque was first dedicated there in 1957. The site is now occupied by 1500 Broadway, which houses offices, retail, and ABC Studios. He was the son of Irish immigrant actor James O'Neill and Mary Ellen Quinlan, who was also of Irish descent.
After suffering from multiple health problems (including depression and alcoholism) over many years, O'Neill ultimately faced a severe Parkinsons-like tremor in his hands which made it impossible for him to write during the last 10 years of his life; he had tried using dictation but found himself unable to compose in that way. While at Tao House, O'Neill had intended to write a cycle of 11 plays chronicling an American family since the 1800s. Only two of these, A Touch of the Poet and More Stately Mansions, were ever completed. As his health worsened, O'Neill lost inspiration for the project and wrote three largely autobiographical plays, The Iceman Cometh, Long Day's Journey into Night, and A Moon for the Misbegotten. He managed to complete Moon for the Misbegotten in 1943, just before leaving Tao House and losing his ability to write. Drafts of many other uncompleted plays were destroyed by Carlotta at Eugene's request.  O'Neill died in Room 401 of the Sheraton Hotel (now Boston University's Shelton Hall) on Bay State Road in Boston, on November 27, 1953, at the age of 65. As he was dying, he whispered his last words: "I knew it. I knew it. Born in a hotel room and died in a hotel room." Dr. Harry Kozol, the lead prosecuting expert of the Patty Hearst trial, treated O'Neill during these last years of illness. He also was present for O'Neill's death and announced the fact to the public.  O'Neill is interred in the Forest Hills Cemetery in Boston's Jamaica Plain neighborhood.  In 1956 Carlotta arranged for his autobiographical play Long Day's Journey into Night to be published, although his written instructions had stipulated that it not be made public until 25 years after his death. It was produced on stage to tremendous critical acclaim and won the Pulitzer Prize in 1957. This last play is widely considered to be his finest. Other posthumously-published works include A Touch of the Poet (1958) and More Stately Mansions (1967).  The United States Postal Service honored O'Neill with a Prominent Americans series (1965-1978) $1 postage stamp.
Answer this question using a quote from the text above:

What illness did he have

Answer:
After suffering from multiple health problems (including depression and alcoholism) over many years, O'Neill ultimately faced a severe Parkinsons-like tremor

Answer the question at the end by quoting:

Charles V (Spanish: Carlos; German: Karl; Italian: Carlo; Latin: Carolus; Dutch: Karel; French: Charles,  24 February 1500 - 21 September 1558) was ruler of both the Spanish Empire as Charles I from 1516 and the Holy Roman Empire as Charles V from 1519, as well as of the lands of the former Duchy of Burgundy from 1506. He stepped down from these and other positions by a series of abdications between 1554 and 1556. Through inheritance, he brought together under his rule extensive territories in western, central, and southern Europe, and the Spanish viceroyalties in the Americas and Asia.
Much of Charles's reign was taken up by conflicts with France, which found itself encircled by Charles's empire while it still maintained ambitions in Italy. In 1520, Charles visited England, where his aunt, Catherine of Aragon, urged her husband, Henry VIII, to ally himself with the emperor. In 1508 Charles was nominated by Henry VII to the Order of the Garter. His Garter stall plate survives in Saint George's Chapel.  The first war with Charles's great nemesis Francis I of France began in 1521. Charles allied with England and Pope Leo X against the French and the Venetians, and was highly successful, driving the French out of Milan and defeating and capturing Francis at the Battle of Pavia in 1525. To gain his freedom, Francis ceded Burgundy to Charles in the Treaty of Madrid, as well as renouncing his support of Henry II's claim over Navarre.  When he was released, however, Francis had the Parliament of Paris denounce the treaty because it had been signed under duress. France then joined the League of Cognac that Pope Clement VII had formed with Henry VIII of England, the Venetians, the Florentines, and the Milanese to resist imperial domination of Italy. In the ensuing war, Charles's sack of Rome (1527) and virtual imprisonment of Pope Clement VII in 1527 prevented the Pope from annulling the marriage of Henry VIII of England and Charles's aunt Catherine of Aragon, so Henry eventually broke with Rome, thus leading to the English Reformation. In other respects, the war was inconclusive. In the Treaty of Cambrai (1529), called the "Ladies' Peace" because it was negotiated between Charles's aunt and Francis' mother, Francis renounced his claims in Italy but retained control of Burgundy.  A third war erupted in 1536. Following the death of the last Sforza Duke of Milan, Charles installed his son Philip in the duchy, despite Francis's claims on it. This war too was inconclusive. Francis failed to conquer Milan, but he succeeded in conquering most of the lands of Charles's ally, the Duke of Savoy, including his capital Turin. A truce at Nice in 1538 on the basis of uti possidetis ended the war but lasted only a short time. War resumed in 1542, with Francis now allied with Ottoman Sultan Suleiman I and Charles once again allied with Henry VIII. Despite the conquest of Nice by a Franco-Ottoman fleet, the French could not advance toward Milan, while a joint Anglo-Imperial invasion of northern France, led by Charles himself, won some successes but was ultimately abandoned, leading to another peace and restoration of the status quo ante bellum in 1544.  A final war erupted with Francis' son and successor, Henry II, in 1551. Henry won early success in Lorraine, where he captured Metz, but French offensives in Italy failed. Charles abdicated midway through this conflict, leaving further conduct of the war to his son, Philip II, and his brother, Ferdinand I, Holy Roman Emperor.

What was Charles' role in the war?
Charles allied with England and Pope Leo X against the French and the Venetians, and was highly successful, driving the French out of Milan