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Edward Nicholas Anderson (November 11, 1900 - April 24, 1974) was an American football player and coach of football and basketball. He served as the head football coach at Columbia College in Dubuque, Iowa, now known as Loras College (1922-1924), DePaul University (1925-1931), the College of the Holy Cross (1933-1938, 1950-1964), and the University of Iowa (1939-1942, 1946-1949), compiling a career college football record of 201-128-15. Anderson was also the head basketball coach at DePaul from 1925 to 1929, tallying a mark of 25-21. Anderson played professional football in the National Football League (NFL) for the Rochester Jeffersons in 1922 and the Chicago Cardinals from 1922 to 1925.

Anderson attended Mason City High School in Mason City, Iowa, before enrolling at the University of Notre Dame. He played for Knute Rockne from 1918 to 1921 and was a teammate of George Gipp. As a senior, he was named a consensus first team All-American and was the team captain of the 1921 Notre Dame football team. In his final three years at Notre Dame, the Irish had a record of 28-1. Anderson's only loss in his final three seasons was to Anderson's home state school, when Notre Dame lost to the Iowa Hawkeyes in 1921, 10-7.  Anderson coached at Columbia College in Dubuque, Iowa, from 1922 to 1924, compiling a 16-6-1 record with one undefeated season. During that time, he was considered for an assistant coaching position at Iowa, but Iowa coach Howard Jones rejected the idea. Anderson served as a player/coach for the Chicago Cardinals (now Arizona Cardinals) professional football team in the early 1920s as well. He played on the Cardinals' controversial championship team in 1925.  That same year, Anderson enrolled at Rush Medical College in Chicago. While in Chicago, Anderson coached football at DePaul University, compiling a 21-22-3 record from 1925 to 1931. He also coached basketball at DePaul from 1925 to 1929, guiding them to a 25-21 record. After graduating from Rush, Anderson took a job as head football coach at the College of the Holy Cross in Massachusetts. He had a record of 47-7-4 in six years at Holy Cross from 1933 to 1938, including undefeated seasons in 1935 and 1937. During that time, Anderson also served as the head of eye, ear, nose, and throat clinic at Boston's Veterans Hospital.
Eddie Anderson (American football coach)