IN: Tu Youyou (Chinese: Tu You You ; pinyin: Tu Youyou; born 30 December 1930) is a Chinese pharmaceutical chemist and educator. She is best known for discovering artemisinin (also known as qinghaosu) and dihydroartemisinin, used to treat malaria, which has saved millions of lives.

Tu Youyou carried on her work in the 1960s and 70s during China's Cultural Revolution, when scientists were denigrated as one of the nine black categories in society according to Maoist theory (or possibly that of the Gang of Four).  In 1967, during the Vietnam War, Ho Chi Minh, the leader of North Vietnam, which was at war against South Vietnam and the United States, asked Chinese Premier Zhou Enlai for help in developing a malaria treatment for his soldiers trooping down the Ho Chi Minh trail, where a majority came down with a form of malaria which is resistant to chloroquine. Because malaria was also a major cause of death in China's southern provinces including Hainan, Yunnan, Guangxi, and Guangdong, Zhou Enlai convinced Mao Zedong to set up a secret drug discovery project, named Project 523 after its starting date, 23 May 1967. Upon joining the project unit, Tu was initially sent to Hainan where she studied patients who had been infected with the disease. During the time she spent there, her husband was banished to the countryside, meaning that her daughter had to be entrusted to a nursery in Beijing.  Scientists worldwide had screened over 240,000 compounds without success. In 1969, Tu Youyou, then 39 years old, had an idea of screening Chinese herbs. She first investigated the Chinese medical classics in history, visiting practitioners of traditional Chinese medicine all over the country on her own. She gathered her findings in a notebook called A Collection of Single Practical Prescriptions for Anti-Malaria. Her notebook summarized 640 prescriptions. Her team also screened over 2,000 traditional Chinese recipes and made 380 herbal extracts, which were tested on mice.  One compound was effective, sweet wormwood (Artemisia annua), which was used for "intermittent fevers," a hallmark of malaria. As Tu also presented at the project seminar, its preparation was described in a 1,600-year-old text, in a recipe titled, "Emergency Prescriptions Kept Up One's Sleeve". At first, it didn't work, because they extracted it with traditional boiling water. Tu Youyou discovered that a low-temperature extraction process could be used to isolate an effective antimalarial substance from the plant; Tu says she was influenced by a traditional Chinese herbal medicine source, The Handbook of Prescriptions for Emergency Treatments, written in 340 by Ge Hong, which states that this herb should be steeped in cold water. This book contained the useful reference to the herb: "A handful of qinghao immersed with two litres of water, wring out the juice and drink it all." After rereading the recipe, Tu realised the hot water had already damaged the active ingredient in the plant; therefore she proposed a method using low-temperature ether to extract the effective compound instead. The animal tests showed it was completely effective in mice and monkeys.  Furthermore, Tu volunteered to be the first human subject. "As head of this research group, I had the responsibility" she said. It was safe, so she conducted successful clinical trials with human patients. Her work was published anonymously in 1977. In 1981, she presented the findings relating to artemisinin at a meeting with the World Health Organization.

What is the name of her work?

OUT: 


IN: William Frederick "Buffalo Bill" Cody (February 26, 1846 - January 10, 1917) was an American scout, bison hunter, and showman. He was born in Le Claire, Iowa Territory (now the U.S. state of Iowa), but he lived for several years in his father's hometown in Toronto Township, Ontario, Canada, before the family returned to the Midwest and settled in the Kansas Territory. Buffalo Bill started working at the age of eleven, after his father's death, and became a rider for the Pony Express at age 14. During the American Civil War, he served the Union from 1863 to the end of the war in 1865.

After his mother recovered, Cody wanted to enlist as a soldier in the Union Army during the American Civil War, but was refused because of his young age. He began working with a freight caravan that delivered supplies to Fort Laramie, in present-day Wyoming. In 1863, at age 17, he enlisted as a teamster with the rank of private in Company H, 7th Kansas Cavalry, and served until discharged in 1865.  The next year, Cody married Louisa Frederici. They had four children. Two died young, while the family was living in Rochester, New York. They and a third child are buried in Mount Hope Cemetery, in Rochester.  Cody went back to work for the Army in 1868 and was Chief of Scouts for the Third Cavalry during the Plains Wars. Part of the time, he scouted for Indians and fought in 16 battles; at other times, he hunted and killed bison to supply the Army and the Kansas Pacific Railroad. In January 1872, Cody was a scout for the highly publicized hunting expedition of the Grand Duke Alexei Alexandrovich of Russia.  Cody was awarded the Medal of Honor in 1872 for gallantry as an Army scout in the Indian Wars. It was revoked in 1913, along with medals of many other recipients, when Congress decided to create a hierarchy of military awards to replace the patchwork which had evolved over time. The result was that the Medal of Honor became the highest military decoration, with its award restricted to "officers or enlisted" personnel who demonstrated bravery "above and beyond the call of duty." The law also allowed the government to retroactively change the honor rolls, resulting in civilian scouts who met neither criterion having their awards rescinded. Cody was one of five scouts affected, whose medals were stripped shortly after Cody died in 1917.  Cody's relatives objected, and over a number of years they wrote repeatedly to Congress seeking reconsideration. All efforts failed, including a 1988 letter to the US Senate from Cody's grandson. A year later the office of Senator Alan K. Simpson of Wyoming took up the cause. Its brief, which argued for the retroactive elevation of these civilian scouts' status to meet the Medal's standards, persuaded the Army Board for Correction of Military Records to restore their medals. To this day, they are the only honorees who were civilians at the time of their award to regain the Medal of Honor.

Was he well liked?

OUT:
Cody was awarded the Medal of Honor in 1872 for gallantry as an Army scout in the Indian Wars.