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Annie Clark was born in Tulsa, Oklahoma. Her mother is a social worker turned administrator for a non-profit organization and her stepfather works in corporate tax administration. Clark's parents divorced when she was three years old, and she moved to Dallas, Texas when she was seven years old with her mother and two older sisters. Her father lives in Tulsa.

In 2006, Clark began recording a studio album, under the stage name St. Vincent. In an interview on The Colbert Report, she said that she "took [her] moniker from a Nick Cave song", which refers to the hospital in which Dylan Thomas died. The reference is to the line "And Dylan Thomas died drunk in / St. Vincent's hospital" from Cave's song "There She Goes my Beautiful World" from the album Abattoir Blues/The Lyre of Orpheus. The name is also a reference to her great-grandmother, whose middle name was St. Vincent.  Clark released her debut album, Marry Me on July 10, 2007 on Beggars Banquet Records. Named after a line from the television show Arrested Development, the album features appearances from drummer Brian Teasley (Man or Astro-man?, The Polyphonic Spree), Mike Garson (David Bowie's longtime pianist), and horn player Louis Schwadron (The Polyphonic Spree).  The album was well received by critics, with Clark being compared to the likes of Kate Bush and David Bowie. Clark was lauded for the album's musical arrangements as well as themes and style; in their review of the album, The AV Club noted: "There's a point where too much happiness turns into madness, and St. Vincent's multi-instrumentalist Annie Clark knows this place well". Pitchfork said "at every turn Marry Me takes the more challenging route of twisting already twisted structures and unusual instrumentation to make them sound perfectly natural and, most importantly, easy to listen to as she overdubs her thrillingly sui generis vision into vibrant life."  The songs featured on Marry Me were largely written when Clark was eighteen and nineteen years old, and, according to Clark, "represented a more idealized version of what life was or what love was or anything in the eyes of someone who hadn't really experienced anything." The album featured its one single, "Paris Is Burning", as well as a music video for "Jesus Saves, I Spend".  In 2008, Clark was nominated for three PLUG Independent Music Awards: New Artist of the Year, Female Artist of the Year, and Music Video of the Year. On March 6, 2008, she won the PLUG Female Artist of the Year award.
St. Vincent (musician)